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Statins Do Not Influence Long-Term Rituximab Clinical Efficiency in Rheumatoid Arthritis Patients
Joint Authors
Mazilu, Diana
Opriş, Daniela
Ionescu, Ruxandra
Gudu, Tania
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-08
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objective.
This longitudinal study aims to determine if statins inhibit the response to rituximab in rheumatoid arthritis (RA) patients.
Methods.
41 patients initiating rituximab were included; 17 patients were exposed to the combination of statins and rituximab.
The total cholesterol, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were assessed.
The clinical response was evaluated using Disease Activity Score (DAS28) and European League against Rheumatism (EULAR) response at 6 and 18 months.
Results.
A tendency of increasing in DAS28 was observed in statin-exposed group but the correlation was very weak (at 18 months: r=0.013, P=0.952).
The statin-exposed status was negatively and very weakly correlated with EULAR response at 6 months (r=-0.073, P=0.661) and 18 months (r=-0.197, P=0.244).
There was a negative correlation between statin-exposed status and inflammatory markers values (ESR and CRP); however, the correlation was very weak.
The use of statin did not influence the cardiovascular risk measured by modified Systematic Coronary Risk Evaluation (mSCORE).
Conclusions.
Long-term significant inhibitory effects of statins on rituximab treatment in RA have not been proved using clinical response scores or biologic markers.
American Psychological Association (APA)
Mazilu, Diana& Gudu, Tania& Ionescu, Ruxandra& Opriş, Daniela. 2014. Statins Do Not Influence Long-Term Rituximab Clinical Efficiency in Rheumatoid Arthritis Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-490731
Modern Language Association (MLA)
Mazilu, Diana…[et al.]. Statins Do Not Influence Long-Term Rituximab Clinical Efficiency in Rheumatoid Arthritis Patients. BioMed Research International No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-490731
American Medical Association (AMA)
Mazilu, Diana& Gudu, Tania& Ionescu, Ruxandra& Opriş, Daniela. Statins Do Not Influence Long-Term Rituximab Clinical Efficiency in Rheumatoid Arthritis Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-490731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490731