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Analysis of Several PLA2 mRNA in Human Meningiomas
Joint Authors
Robert, Sandrine
Labrousse, François
Weinbreck, Nicolas
Denizot, Yves
Moreau, Jean-Jacques
De Armas, Rafael
Durand, Karine
Caire, François
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
In view of the important oncogenic action of phospholipase A2(PLA2) we investigated PLA2 transcripts in human meningiomas.
Real-time PCR was used to investigate PLA2 transcripts in 26 human meningioma tumors.
Results indicated that three Ca2+-dependent high molecular weight PLA2 (PLA2-IVA, PLA2-IVB, PLA2-IVC), one Ca2+-independent high molecular weight PLA2 (PLA2-VI) and five low molecular weight secreted forms of PLA2 (PLA2-IB, PLA2-IIA, PLA2-III, PLA2-V, and PLA2-XII) are expressed with PLA2-IVA, PLA2-IVB, PLA2-VI, and PLA2-XIIA as the major expressed forms.
PLA2-IIE, PLA2-IIF, PLA2-IVD, and PLA2-XIIB are not detected.
Plasma (PLA2-VIIA) and intracellular (PLA2-VIIB) platelet-activating factor acetylhydrolase transcripts are expressed in human meningiomas.
However no difference was found for PLA2 transcript amounts in relation to the tumor grade, the subtype of meningiomas, the presence of inflammatory infiltrated cells, of an associated edema, mitosis, brain invasion, vascularisation or necrosis.
In conclusion numerous genes encoding multiples forms of PLA2 are expressed in meningiomas where they might act on the phospholipid remodeling and on the local eicosanoid and/or cytokine networks.
American Psychological Association (APA)
Denizot, Yves& De Armas, Rafael& Durand, Karine& Robert, Sandrine& Moreau, Jean-Jacques& Caire, François…[et al.]. 2010. Analysis of Several PLA2 mRNA in Human Meningiomas. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-490734
Modern Language Association (MLA)
Denizot, Yves…[et al.]. Analysis of Several PLA2 mRNA in Human Meningiomas. Mediators of Inflammation No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-490734
American Medical Association (AMA)
Denizot, Yves& De Armas, Rafael& Durand, Karine& Robert, Sandrine& Moreau, Jean-Jacques& Caire, François…[et al.]. Analysis of Several PLA2 mRNA in Human Meningiomas. Mediators of Inflammation. 2010. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-490734
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490734