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Activation of Nrf2-Regulated Glutathione Pathway Genes by Ischemic Preconditioning
Joint Authors
Bell, Karen F. S.
al-Mubarak, Bashayer
Hardingham, Giles E.
Fowler, Jill H.
Horsburgh, Karen
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Prophylactic pharmacological activation of astrocytic gene expression driven by the transcription factor Nrf2 boosts antioxidant defences and protects against neuronal loss in ischemia and other disease models.
However, the role of Nrf2 in mediating endogenous neuroprotective responses is less clear.
We recently showed that Nrf2 is activated by mild oxidative stress in both rodent and human astrocytes.
Moreover, brief exposure to ischemic conditions was found to activate Nrf2 both in vivo and in vitro, and this was found to contribute to neuroprotective ischemic preconditioning.
Here we show that transient ischemic conditions in vitro and in vivo cause an increase in the expression of Nrf2 target genes associated with the glutathione pathway, including those involved in glutathione biosynthesis and cystine uptake.
Taken together, these studies indicate that astrocytic Nrf2 may represent an important mediator of endogenous neuroprotective preconditioning pathways.
American Psychological Association (APA)
Bell, Karen F. S.& Fowler, Jill H.& al-Mubarak, Bashayer& Horsburgh, Karen& Hardingham, Giles E.. 2011. Activation of Nrf2-Regulated Glutathione Pathway Genes by Ischemic Preconditioning. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-490743
Modern Language Association (MLA)
Bell, Karen F. S.…[et al.]. Activation of Nrf2-Regulated Glutathione Pathway Genes by Ischemic Preconditioning. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-490743
American Medical Association (AMA)
Bell, Karen F. S.& Fowler, Jill H.& al-Mubarak, Bashayer& Horsburgh, Karen& Hardingham, Giles E.. Activation of Nrf2-Regulated Glutathione Pathway Genes by Ischemic Preconditioning. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-490743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490743