Vitamin E and N-Acetylcysteine as Antioxidant Adjuvant Therapy in Children with Acute Lymphoblastic Leukemia
Joint Authors
EL-Dakroory, Sahar
al-Haggar, Mohammad
Fouda, Ashraf
EL-Ashry, Rasha
al-Tonbary, Youssef
Azzam, Hanan
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-20
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Although cancer therapies have experienced great success nowadays, yet the associated toxic response and free radicals formation have resulted in significant number of treatment-induced deaths rather than disease-induced fatalities.
Complications of chemotherapy have forced physicians to study antioxidant use as adjunctive treatment in cancer.
This study aimed to evaluate the antioxidant role of vitamin E and N-acetyl cysteine (NAC) in overcoming treatment-induced toxicity in acute lymphoblastic leukaemia (ALL) during the intensive period of chemo-/radiotherapy, almost the first two months of treatment.
Forty children newly diagnosed with ALL were enrolled in this study.
Twenty children (group I) have taken vitamin E and NAC supplementations with chemotherapy and the other twenty children (group II) have not taken any adjuvant antioxidant therapy.
They were evaluated clinically for the occurrence of complications and by the laboratory parameters (blood levels of glutathione peroxidase (Glu.PX) antioxidant enzyme, malondialdehyde (MDA), tumor necrosis factor-α (TNF-α), liver enzymes, and bone marrow picture).
Results revealed reduced chemotherapy and radiotherapy toxicity as evidenced by decreasing level of MDA, increasing level of Glu.Px and decreased occurrence of toxic hepatitis, haematological complications, and need for blood and platelet transfusions in group I compared to group II.
We can conclude that vitamin E and NAC have been shown to be effective as antioxidant adjuvant therapy in children with ALL to reduce chemo-/radiotherapy-related toxicities during the initial period of treatment.
American Psychological Association (APA)
al-Tonbary, Youssef& al-Haggar, Mohammad& EL-Ashry, Rasha& EL-Dakroory, Sahar& Azzam, Hanan& Fouda, Ashraf. 2009. Vitamin E and N-Acetylcysteine as Antioxidant Adjuvant Therapy in Children with Acute Lymphoblastic Leukemia. Advances in Hematology،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-490749
Modern Language Association (MLA)
al-Tonbary, Youssef…[et al.]. Vitamin E and N-Acetylcysteine as Antioxidant Adjuvant Therapy in Children with Acute Lymphoblastic Leukemia. Advances in Hematology No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-490749
American Medical Association (AMA)
al-Tonbary, Youssef& al-Haggar, Mohammad& EL-Ashry, Rasha& EL-Dakroory, Sahar& Azzam, Hanan& Fouda, Ashraf. Vitamin E and N-Acetylcysteine as Antioxidant Adjuvant Therapy in Children with Acute Lymphoblastic Leukemia. Advances in Hematology. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-490749
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490749