Association of Inherited Thrombophilia with Recurrent Pregnancy Loss in Palestinian Women

Abstract EN

Objective.

This study aimed at analyzing the association between recurrent pregnancy loss (RPL) and factor V G1691A (FVL), prothrombin G20210 (FII); and MTHFR C677T (MTHFR) in Palestinian women.

Method.

We studied 329 Palestinian women with RPL and/or stillbirth (SB); and compared them to 402 healthy reproductive Palestinian women.

Cases and controls were tested for the above mutations.

Odds ratio (OR) at confidence interval (CI) of 95% was used as a measure of association between the mutations and RPL.

Results.

Our statistical analysis showed a slightly increased association, which was not significant between FVL and RPL (OR 1.32, 95% CI 0.90–1.94), and no association between FII (OR 0.84, 95% CI 0.38–1.92), MTHFR (OR 0.58, 95% CI 0.32–1.03), and RPL.

Further analysis of RPL subgroups revealed an association between FVL and first-trimester loss (OR 1.33, 95% CI 0.892–1.989), and second-trimester loss (OR 1.13, 95% CI 0.480–2.426), both were not statistically significant.

Furthermore, the only statistically significant association was between FVL and SB (OR 2.0, 95% CI 1.05–3.70).

Conclusion.

Our analysis had failed to find a significant association between FVL, FII, MTHFR; and RPL in either the first or second trimester.

FVL was significantly associated with fetal loss if the loss was a stillbirth.