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Diagnostic and Prognostic Role of Preoperative Circulating CA 15-3, CA 125, and Beta-2 Microglobulin in Renal Cell Carcinoma
Joint Authors
Vavallo, Antonio
Lucarelli, Giuseppe
Grandaliano, Giuseppe
Gesualdo, Loreto
Battaglia, Michele
Selvaggi, Francesco Paolo
Galleggiante, Vanessa
Castellano, Giuseppe
Larocca, Angela Maria Vittoria
Ditonno, Pasquale
Bettocchi, Carlo
Rutigliano, Monica
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
CA 15-3, CA 125 and β-2 microglobulin are three common tumor markers currently used for diagnosis, prognosis, assessment of therapeutic response, and/or to evaluate recurrence in breast and ovarian cancer and malignant lymphoproliferative disorders, respectively.
In the present prospective study we assessed the role of these three serum proteins as biomarkers for renal cell carcinoma (RCC), as well as any association between tumor marker levels and clinical-pathological parameters.
CA 15-3, CA 125, and β-2 microglobulin were preoperatively measured in 332 patients who underwent nephrectomy for RCC.
Estimates of cancer-specific survival (CSS) was calculated according to the Kaplan-Meier method.
Multivariate analysis was performed to identify the most significant variables for predicting CSS.
Preoperatively, 35.2% (n=117), 9.6% (n=32) and 30.4% (n=101) of the patients had abnormal levels of CA 15-3, CA 125 and β-2 microglobulin, respectively.
Statistically significant differences resulted between CA 15-3, CA 125 and β-2 microglobulin values and tumor size, Fuhrman grade, presence of lymph node, and visceral metastases.
CSS was significantly decreased for patients with high levels of CA 15-3, CA 125, and β-2 microglobulin (P<0.0001, P<0.0001, and P=0.001, resp.).
At multivariate analysis only age, the presence of visceral metastases, and high levels of CA 15-3 were independent adverse prognostic factors for CSS.
American Psychological Association (APA)
Lucarelli, Giuseppe& Ditonno, Pasquale& Bettocchi, Carlo& Vavallo, Antonio& Rutigliano, Monica& Galleggiante, Vanessa…[et al.]. 2014. Diagnostic and Prognostic Role of Preoperative Circulating CA 15-3, CA 125, and Beta-2 Microglobulin in Renal Cell Carcinoma. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-490759
Modern Language Association (MLA)
Lucarelli, Giuseppe…[et al.]. Diagnostic and Prognostic Role of Preoperative Circulating CA 15-3, CA 125, and Beta-2 Microglobulin in Renal Cell Carcinoma. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-490759
American Medical Association (AMA)
Lucarelli, Giuseppe& Ditonno, Pasquale& Bettocchi, Carlo& Vavallo, Antonio& Rutigliano, Monica& Galleggiante, Vanessa…[et al.]. Diagnostic and Prognostic Role of Preoperative Circulating CA 15-3, CA 125, and Beta-2 Microglobulin in Renal Cell Carcinoma. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-490759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490759