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Transgenic Epigenetics : Using Transgenic Organisms to Examine Epigenetic Phenomena
Author
Source
Genetics Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Non-model organisms are generally more difficult and/or time consuming to work with than model organisms.
In addition, epigenetic analysis of model organisms is facilitated by well-established protocols, and commercially-available reagents and kits that may not be available for, or previously tested on, non-model organisms.
Given the evolutionary conservation and widespread nature of many epigenetic mechanisms, a powerful method to analyze epigenetic phenomena from non-model organisms would be to use transgenic model organisms containing an epigenetic region of interest from the non-model.
Interestingly, while transgenic Drosophila and mice have provided significant insight into the molecular mechanisms and evolutionary conservation of the epigenetic processes that target epigenetic control regions in other model organisms, this method has so far been under-exploited for non-model organism epigenetic analysis.
This paper details several experiments that have examined the epigenetic processes of genomic imprinting and paramutation, by transferring an epigenetic control region from one model organism to another.
These cross-species experiments demonstrate that valuable insight into both the molecular mechanisms and evolutionary conservation of epigenetic processes may be obtained via transgenic experiments, which can then be used to guide further investigations and experiments in the species of interest.
American Psychological Association (APA)
McEachern, Lori A.. 2012. Transgenic Epigenetics : Using Transgenic Organisms to Examine Epigenetic Phenomena. Genetics Research International،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-490766
Modern Language Association (MLA)
McEachern, Lori A.. Transgenic Epigenetics : Using Transgenic Organisms to Examine Epigenetic Phenomena. Genetics Research International No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-490766
American Medical Association (AMA)
McEachern, Lori A.. Transgenic Epigenetics : Using Transgenic Organisms to Examine Epigenetic Phenomena. Genetics Research International. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-490766
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490766