Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia : Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury
Joint Authors
Ribeiro, Edson A.
Poli-de-Figueiredo, Luiz F.
Rocha-e-Silva, Mauricio
Galvao, Flavio H. F.
Vincenzi, Rodrigo
Margarido, Nelson
Cruz, Ruy J.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Pentoxifylline (PTX) has been shown to have beneficial effects on microcirculatory blood flow.
In this study we evaluate the potential hemodynamic and metabolic benefits of PTX during hepatic ischemia.
We also test the hypothesis that portal PTX infusion can minimize the I/R injury when compared to systemic infusion.
Methods.
Twenty-four dogs (18.1±0.7 kg) were subjected to portal triad occlusion (PTO) for 45 min.
The animals were assigned to 3 groups: CT (control, PTO, n=8), PTX-syst (PTO + 25 mg/Kg of PTX IV, n=8), and PTX-pv (PTO + 25 mg/Kg of PTX in the portal vein, n=8).
Animals were followed for 120 min.
Systemic hemodynamics, gastrointestinal tract perfusion, oxygen-derived variables, and liver enzymes were evaluated throughout the experiment.
Results.
Animals treated with PTX presented significantly higher CO in the first hour after reperfusion, when compared to the CT (~3.7 vs.
2.1 L/min, P<0.05).
Alanine aminotransferase (ALT) was similar in the PTX groups two hours after reperfusion but significantly higher in the CT (227 vs.
~64 U/L, P<0.05).
Conclusion.
PTX infusion was associated with hemodynamic benefits and was able to minimize liver injury during normothermic hepatic I/R.
However, local PTX infusion was not associated with any significant advantage over systemic route.
American Psychological Association (APA)
Ribeiro, Edson A.& Poli-de-Figueiredo, Luiz F.& Vincenzi, Rodrigo& Galvao, Flavio H. F.& Margarido, Nelson& Rocha-e-Silva, Mauricio…[et al.]. 2013. Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia : Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury. HPB Surgery،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-490770
Modern Language Association (MLA)
Ribeiro, Edson A.…[et al.]. Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia : Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury. HPB Surgery No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-490770
American Medical Association (AMA)
Ribeiro, Edson A.& Poli-de-Figueiredo, Luiz F.& Vincenzi, Rodrigo& Galvao, Flavio H. F.& Margarido, Nelson& Rocha-e-Silva, Mauricio…[et al.]. Intraportal versus Systemic Pentoxifylline Infusion after Normothermic Liver Ischemia : Effects on Regional Blood Flow Redistribution and Hepatic Ischemia-Reperfusion Injury. HPB Surgery. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-490770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490770