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Advanced Malignant Melanoma : Immunologic and Multimodal Therapeutic Strategies
Joint Authors
Jaeger, Dirk
Halama, Niels
Zoernig, Inka
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-03-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Immunologic treatment strategies are established in malignant melanoma treatment, mainly focusing on Interleukin-2 in advanced disease and interferon alpha in the adjuvant situation.
In advanced disease, therapies with IL-2, interferon and different chemotherapeutic agents were not associated with better patient survival in the vast majority of patients.
Therefore, an overview of novel immunological agents and combined therapeutic approaches is presented in this review, covering allogenic and autologous vaccine strategies, dendritic cell vaccination, strategies for adoptive immunotherapy and T cell receptor gene transfer, treatment with cytokines and monoclonal antibodies against the CTLA-4 antigen.
As emerging treatment strategies are based on individual molecular and immunological characterization of individual tumors/patients, tailored targeted drug therapies move into the focus of treatment strategies.
Multimodal combination therapies with considerable potential in altering the immune response in malignant melanoma patients are currently emerging.
As oncology moves forward into the field of personalized therapies, a careful molecular and immunological characterization of patients is crucial to select patients for individual targeted treatment.
American Psychological Association (APA)
Halama, Niels& Zoernig, Inka& Jaeger, Dirk. 2010. Advanced Malignant Melanoma : Immunologic and Multimodal Therapeutic Strategies. Journal of Oncology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-490777
Modern Language Association (MLA)
Halama, Niels…[et al.]. Advanced Malignant Melanoma : Immunologic and Multimodal Therapeutic Strategies. Journal of Oncology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-490777
American Medical Association (AMA)
Halama, Niels& Zoernig, Inka& Jaeger, Dirk. Advanced Malignant Melanoma : Immunologic and Multimodal Therapeutic Strategies. Journal of Oncology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-490777
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490777