Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant
Joint Authors
Yu, Xiao-Hong
Liu, Chao-Qun
Jin, Bo
Lu, Ping
Yang, Ying-Xiang
Yeo, Anthony E. T.
Sun, Tao
Qiu, Hui-Bin
Fu, Shan-Feng
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-05
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
dsRNA can be detected by pattern recognition receptors, for example, TLR3, MDA-5, NLRP3 to induce proinflammatory cytokines responsible for innate/adaptive immunity.
Recognized by endosomal TLR3 in myeloid DCs (mDCs), dsRNA can activate mDCs into mature antigen presenting cells (mAPCs) which in turn present antigen epitopes with MHC-I molecules to naïve T cells.
Coadministration of protein and synthetic dsRNA analogues can elicit an antigen-specific Th1-polarized immune response which stimulates the CD8+ CTL response and possibly dampen Th17 response.
Synthetic dsRNA analogues have been tested as vaccine adjuvant against viral infections in animal models.
However, a dsRNA receptor, TLR3 can be expressed in tumor cells while other members of TLR family, for example, TLR4 and TLR2 have been shown to promote tumor progression, metastasis, and chemoresistance.
Thus, the promising potential of dsRNA analogues as a tumor therapeutic vaccine adjuvant should be evaluated cautiously.
American Psychological Association (APA)
Jin, Bo& Sun, Tao& Yu, Xiao-Hong& Liu, Chao-Qun& Yang, Ying-Xiang& Lu, Ping…[et al.]. 2010. Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-490820
Modern Language Association (MLA)
Jin, Bo…[et al.]. Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-17.
https://search.emarefa.net/detail/BIM-490820
American Medical Association (AMA)
Jin, Bo& Sun, Tao& Yu, Xiao-Hong& Liu, Chao-Qun& Yang, Ying-Xiang& Lu, Ping…[et al.]. Immunomodulatory Effects of dsRNA and Its Potential as Vaccine Adjuvant. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-17.
https://search.emarefa.net/detail/BIM-490820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490820