Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-03
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Digital ulcers are a well-known problem in patients with systemic sclerosis.
Lower extremity ulcers are less prevalent but are also a challenging and underestimated complication of the disease causing important pain and morbidity.
Bosentan, an oral dual endothelin receptor antagonist, has been shown to be effective in preventing digital ulcers in patients with systemic sclerosis.
A few recent observations showed the efficacy of bosentan for accelerating the healing of nondigital ulcers in scleroderma patients.
This report deals with a 48-year-old patient with systemic sclerosis who developed painful ulcers on the left ankle and hallux.
The ulcers were refractory to a combination of vasodilator therapy with a calcium antagonist and several courses of intravenous prostanoids, low molecular weight heparin, aspirin, simvastatin, and intensive local treatment.
Bosentan treatment showed spectacular healing of the ulcers already after 4 months of therapy.
This case supports the previous few observations of accelerating wound healing of lower extremity ulcers in systemic sclerosis patients with bosentan treatment.
American Psychological Association (APA)
Naert, Alix& De Haes, Petra. 2013. Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient. Case Reports in Medicine،Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-490840
Modern Language Association (MLA)
Naert, Alix& De Haes, Petra. Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient. Case Reports in Medicine No. 2013 (2013), pp.1-3.
https://search.emarefa.net/detail/BIM-490840
American Medical Association (AMA)
Naert, Alix& De Haes, Petra. Successful Treatment with Bosentan of Lower Extremity Ulcers in a Scleroderma Patient. Case Reports in Medicine. 2013. Vol. 2013, no. 2013, pp.1-3.
https://search.emarefa.net/detail/BIM-490840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490840