Therapies with Emerging Evidence of Efficacy : Avotermin for the Improvement of Scarring
Joint Authors
Bush, Jim
So, Karen
Ferguson, Mark W. J.
Mason, Tracey
Occleston, Nick L.
O'Kane, Sharon
Source
Dermatology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Many patients are dissatisfied with scars on both visible and non-visible body sites and would value any opportunity to improve or minimise scarring following surgery.
Approximately 44 million procedures in the US and 42 million procedures in the EU per annum could benefit from scar reduction therapy.
A wide range of non-invasive and invasive techniques have been used in an attempt to improve scarring although robust, prospective clinical trials to support the efficacy of these therapies are lacking.
Differences in wound healing and scar outcome between early fetal and adult wounds led to interest in the role of the TGFβ family of cytokines in scar formation and the identification of TGFβ3 (avotermin) as a potential therapeutic agent for the improvement of scar appearance.
Extensive pre-clinical and human Phase I and II clinical trial programmes have confirmed the scar improving efficacy of avotermin which produces macroscopic and histological improvements in scar architecture, with improved restitution of the epidermis and an organisation of dermal extracellular matrix that more closely resembles normal skin.
Avotermin is safe and well tolerated and is currently in Phase III of clinical development, with the first study, in patients undergoing scar revision surgery, fully recruited.
American Psychological Association (APA)
Bush, Jim& So, Karen& Mason, Tracey& Occleston, Nick L.& O'Kane, Sharon& Ferguson, Mark W. J.. 2010. Therapies with Emerging Evidence of Efficacy : Avotermin for the Improvement of Scarring. Dermatology Research and Practice،Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-490843
Modern Language Association (MLA)
Bush, Jim…[et al.]. Therapies with Emerging Evidence of Efficacy : Avotermin for the Improvement of Scarring. Dermatology Research and Practice No. 2010 (2010), pp.1-6.
https://search.emarefa.net/detail/BIM-490843
American Medical Association (AMA)
Bush, Jim& So, Karen& Mason, Tracey& Occleston, Nick L.& O'Kane, Sharon& Ferguson, Mark W. J.. Therapies with Emerging Evidence of Efficacy : Avotermin for the Improvement of Scarring. Dermatology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-6.
https://search.emarefa.net/detail/BIM-490843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490843