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Regulating the Regulators : The Post-Translational Code of Class I HDAC1 and HDAC2
Joint Authors
Chiocca, Susanna
Segré, Chiara V.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-09
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Class I histone deacetylases (HDACs) are cellular enzymes expressed in many tissues and play crucial roles in differentiation, proliferation, and cancer.
HDAC1 and HDAC2 in particular are highly homologous proteins that show redundant or specific roles in different cell types or in response to different stimuli and signaling pathways.
The molecular details of this dual regulation are largely unknown.
HDAC1 and HDAC2 are not only protein modifiers, but are in turn regulated by post-translational modifications (PTMs): phosphorylation, acetylation, ubiquitination, SUMOylation, nitrosylation, and carbonylation.
Some of these PTMs occur and crosstalk specifically on HDAC1 or HDAC2, creating a rational “code” for a differential, context-related regulation.
The global comprehension of this PTM code is central for dissecting the role of single HDAC1 and HDAC2 in physiology and pathology.
American Psychological Association (APA)
Segré, Chiara V.& Chiocca, Susanna. 2010. Regulating the Regulators : The Post-Translational Code of Class I HDAC1 and HDAC2. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-490860
Modern Language Association (MLA)
Segré, Chiara V.& Chiocca, Susanna. Regulating the Regulators : The Post-Translational Code of Class I HDAC1 and HDAC2. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-490860
American Medical Association (AMA)
Segré, Chiara V.& Chiocca, Susanna. Regulating the Regulators : The Post-Translational Code of Class I HDAC1 and HDAC2. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-490860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490860