Regulation of Immune Responses by Histone Deacetylase Inhibitors
Joint Authors
Licciardi, Paul V.
Karagiannis, Tom C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Both genetic and epigenetic factors are important regulators of the immune system.
There is an increasing body of evidence attesting to epigenetic modifications that influence the development of distinct innate and adaptive immune response cells.
Chromatin remodelling via acetylation, methylation, phosphorylation, and ubiquitination of histone proteins as well as DNA, methylation is epigenetic mechanisms by which immune gene expression can be controlled.
In this paper, we will discuss the role of epigenetics in the regulation of host immunity, with particular emphasis on histone deacetylase inhibitors.
In particular, the role of HDAC inhibitors as a new class of immunomodulatory therapeutics will also be reviewed.
American Psychological Association (APA)
Licciardi, Paul V.& Karagiannis, Tom C.. 2012. Regulation of Immune Responses by Histone Deacetylase Inhibitors. ISRN Hematology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490863
Modern Language Association (MLA)
Licciardi, Paul V.& Karagiannis, Tom C.. Regulation of Immune Responses by Histone Deacetylase Inhibitors. ISRN Hematology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-490863
American Medical Association (AMA)
Licciardi, Paul V.& Karagiannis, Tom C.. Regulation of Immune Responses by Histone Deacetylase Inhibitors. ISRN Hematology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490863
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490863