Regulation of Immune Responses by Histone Deacetylase Inhibitors

Joint Authors

Licciardi, Paul V.
Karagiannis, Tom C.

Source

ISRN Hematology

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-03-18

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Diseases

Abstract EN

Both genetic and epigenetic factors are important regulators of the immune system.

There is an increasing body of evidence attesting to epigenetic modifications that influence the development of distinct innate and adaptive immune response cells.

Chromatin remodelling via acetylation, methylation, phosphorylation, and ubiquitination of histone proteins as well as DNA, methylation is epigenetic mechanisms by which immune gene expression can be controlled.

In this paper, we will discuss the role of epigenetics in the regulation of host immunity, with particular emphasis on histone deacetylase inhibitors.

In particular, the role of HDAC inhibitors as a new class of immunomodulatory therapeutics will also be reviewed.

American Psychological Association (APA)

Licciardi, Paul V.& Karagiannis, Tom C.. 2012. Regulation of Immune Responses by Histone Deacetylase Inhibitors. ISRN Hematology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490863

Modern Language Association (MLA)

Licciardi, Paul V.& Karagiannis, Tom C.. Regulation of Immune Responses by Histone Deacetylase Inhibitors. ISRN Hematology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-490863

American Medical Association (AMA)

Licciardi, Paul V.& Karagiannis, Tom C.. Regulation of Immune Responses by Histone Deacetylase Inhibitors. ISRN Hematology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490863

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-490863