Reconstruction of Protein-Protein Interaction Network of Insulin Signaling in Homo Sapiens
Joint Authors
Ülgen, Kutlu Ö.
Eren Toku, Aysun
Durmuş Tekir, Saliha
Ümit, Pelin
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Diabetes is one of the most prevalent diseases in the world.
Type 1 diabetes is characterized by the failure of synthesizing and secreting of insulin because of destroyed pancreatic β-cells.
Type 2 diabetes, on the other hand, is described by the decreased synthesis and secretion of insulin because of the defect in pancreatic β-cells as well as by the failure of responding to insulin because of malfunctioning of insulin signaling.
In order to understand the signaling mechanisms of responding to insulin, it is necessary to identify all components in the insulin signaling network.
Here, an interaction network consisting of proteins that have statistically high probability of being biologically related to insulin signaling in Homo sapiens was reconstructed by integrating Gene Ontology (GO) annotations and interactome data.
Furthermore, within this reconstructed network, interacting proteins which mediate the signal from insulin hormone to glucose transportation were identified using linear paths.
The identification of key components functioning in insulin action on glucose metabolism is crucial for the efforts of preventing and treating type 2 diabetes mellitus.
American Psychological Association (APA)
Durmuş Tekir, Saliha& Ümit, Pelin& Eren Toku, Aysun& Ülgen, Kutlu Ö.. 2010. Reconstruction of Protein-Protein Interaction Network of Insulin Signaling in Homo Sapiens. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-490871
Modern Language Association (MLA)
Durmuş Tekir, Saliha…[et al.]. Reconstruction of Protein-Protein Interaction Network of Insulin Signaling in Homo Sapiens. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-490871
American Medical Association (AMA)
Durmuş Tekir, Saliha& Ümit, Pelin& Eren Toku, Aysun& Ülgen, Kutlu Ö.. Reconstruction of Protein-Protein Interaction Network of Insulin Signaling in Homo Sapiens. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-490871
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490871