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Heme Induction with Delta-Aminolevulinic Acid Stimulates an Increase in Water and Electrolyte Excretion
Joint Authors
Jackson, Keith E.
Jackson, Debra W.
Quadri, Syed
Dean, Courtney
Prathipati, Priyanka
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
Studies were performed to examine hemodynamic and renal function before and after acute induction of the endogenous CO system with delta-aminolevulinic acid (DALA), which drives HO activity.
Methods.
In vivo studies were conducted on Inactin-anesthetized male Sprague Dawley rats (250–300 g) either with or without chronic pretreatment with L-NAME (50 mg/Kg, q12 hours x4d).
Results.
DALA (80 μmol/Kg, IV bolus) administration acutely increased endogenous CO production and HO-1 protein.
In untreated and L-NAME-pretreated rats, DALA did not alter BP, GFR, or RBF but increased UF, UNaV, and UKV (untreated: Δ108.8 ± 0.28%, 172.1 ± 18.4%, and 165.2 ± 45.9%; pretreated: Δ109.4 ± 0.29%, 187.3 ± 26.9%, and 197.2 ± 45.7%).
Acute administration of biliverdin (20 mg/kg, IV) and bilirubin (30 mg/kg, IV) to similarly treated animals did not alter UF, UNaV, and UKV.
Conclusion.
These results demonstrate that heme oxygenase induction increases urine and electrolyte excretion and suggest a direct tubular action of endogenous carbon monoxide.
American Psychological Association (APA)
Quadri, Syed& Jackson, Debra W.& Prathipati, Priyanka& Dean, Courtney& Jackson, Keith E.. 2012. Heme Induction with Delta-Aminolevulinic Acid Stimulates an Increase in Water and Electrolyte Excretion. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490874
Modern Language Association (MLA)
Quadri, Syed…[et al.]. Heme Induction with Delta-Aminolevulinic Acid Stimulates an Increase in Water and Electrolyte Excretion. International Journal of Hypertension No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-490874
American Medical Association (AMA)
Quadri, Syed& Jackson, Debra W.& Prathipati, Priyanka& Dean, Courtney& Jackson, Keith E.. Heme Induction with Delta-Aminolevulinic Acid Stimulates an Increase in Water and Electrolyte Excretion. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490874
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490874