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Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury
Joint Authors
Dubový, Petr
Klusáková, Ilona
Hradilová Svíženská, Ivana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Activated Schwann cells distal to nerve injury upregulate inflammatory mediators, including cytokines.
The goal of the present study was to investigate expression of proinflammatory (IL-1β, TNFα) and anti-inflammatory cytokines (IL-4, IL-10) in activated Schwann cells in relation to growing axons distal to crush injury of rat sciatic nerves.
Seven days from sciatic nerve crush, transverse cryostat sections were cut 5 mm distal to lesion and incubated for double immunostaining to indicate Schwann cells (GFAP or S100b) and individual investigated cytokines or to demonstrate growing axons (GAP43).
The Schwann cells of naïve sciatic nerves and those removed from sham-operated rats displayed similar weak immunoreactivity for the investigated cytokines.
In contrast, increased intensity of cytokine immunofluorescence was found in Schwann cells distal to crush lesion.
The cytokine-positive Schwann cells were found in close contact with growing axons detected by immunostaining for GAP43.
The results of immunohistochemical analysis distal to nerve crush injury suggest that inflammatory profiling of Schwann cells including upregulation of both pro- and anti-inflammatory cytokines does not prevent growth of axons distal to nerve crush injury.
American Psychological Association (APA)
Dubový, Petr& Klusáková, Ilona& Hradilová Svíženská, Ivana. 2014. Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-490880
Modern Language Association (MLA)
Dubový, Petr…[et al.]. Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-490880
American Medical Association (AMA)
Dubový, Petr& Klusáková, Ilona& Hradilová Svíženská, Ivana. Inflammatory Profiling of Schwann Cells in Contact with Growing Axons Distal to Nerve Injury. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-490880
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490880