Hypoglycemic Properties of Oxovanadium (IV)‎ Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice

Abstract EN

In order to avoid low absorption, incorporation, and undesirable side effects of inorganic oxovanadium compounds, the antidiabetic activities of organic oxovanadium (IV) compounds in alloxan-induced diabetic mice were investigated.

Vanadyl carboxymethyl carrageenan (VOCCA) and vanadyl carboxymethyl chitosan (VOCCH) were synthesized and administrated through intragastric administration in different doses for 20 days in alloxan-induced diabetic mice.

Glibenclamide was administrated as the positive control.

Our results showed that low-dose group, middle-dose group, and high-dose group of VOCCA and VOCCH could significantly reduce the levels of blood glucose (P<0.05) compared with untreated group, but not in normal mice.

Besides, high-dose groups of VOCCA and VOCCH exhibited more significant hypoglycemic activities (P<0.01).

After treated with VOCCH, the oral glucose tolerance of high-dose group of VOCCH was improved compared with model control group (P<0.05).