Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice
Joint Authors
Feng, Dawei
Yi, Yuetao
Zhang, Hongyu
Wang, Yipeng
Qin, Song
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In order to avoid low absorption, incorporation, and undesirable side effects of inorganic oxovanadium compounds, the antidiabetic activities of organic oxovanadium (IV) compounds in alloxan-induced diabetic mice were investigated.
Vanadyl carboxymethyl carrageenan (VOCCA) and vanadyl carboxymethyl chitosan (VOCCH) were synthesized and administrated through intragastric administration in different doses for 20 days in alloxan-induced diabetic mice.
Glibenclamide was administrated as the positive control.
Our results showed that low-dose group, middle-dose group, and high-dose group of VOCCA and VOCCH could significantly reduce the levels of blood glucose (P<0.05) compared with untreated group, but not in normal mice.
Besides, high-dose groups of VOCCA and VOCCH exhibited more significant hypoglycemic activities (P<0.01).
After treated with VOCCH, the oral glucose tolerance of high-dose group of VOCCH was improved compared with model control group (P<0.05).
American Psychological Association (APA)
Zhang, Hongyu& Yi, Yuetao& Feng, Dawei& Wang, Yipeng& Qin, Song. 2011. Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-490885
Modern Language Association (MLA)
Zhang, Hongyu…[et al.]. Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-490885
American Medical Association (AMA)
Zhang, Hongyu& Yi, Yuetao& Feng, Dawei& Wang, Yipeng& Qin, Song. Hypoglycemic Properties of Oxovanadium (IV) Coordination Compounds with Carboxymethyl-Carrageenan and Carboxymethyl-Chitosan in Alloxan-Induced Diabetic Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-490885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490885