Molecular Determinants of Cav1.2 Calcium Channel Inactivation
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Voltage-gated L-type Cav1.2 calcium channels couple membrane depolarization to transient increase in cytoplasmic free Ca2+ concentration that initiates a number of essential cellular functions including cardiac and vascular muscle contraction, gene expression, neuronal plasticity, and exocytosis.
Inactivation or spontaneous termination of the calcium current through Cav1.2 is a critical step in regulation of these processes.
The pathophysiological significance of this process is manifested in hypertension, heart failure, arrhythmia, and a number of other diseases where acceleration of the calcium current decay should present a benefit function.
The central issue of this paper is the inactivation of the Cav1.2 calcium channel mediated by multiple determinants.
American Psychological Association (APA)
Soldatov, Nikolai M.. 2012. Molecular Determinants of Cav1.2 Calcium Channel Inactivation. ISRN Molecular Biology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490901
Modern Language Association (MLA)
Soldatov, Nikolai M.. Molecular Determinants of Cav1.2 Calcium Channel Inactivation. ISRN Molecular Biology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-490901
American Medical Association (AMA)
Soldatov, Nikolai M.. Molecular Determinants of Cav1.2 Calcium Channel Inactivation. ISRN Molecular Biology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-490901
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490901