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Endocytosis and Sphingolipid Scavenging in Leishmania mexicana Amastigotes
Joint Authors
Denny, Paul W.
Harding, Clare R.
Ali, Hayder Z.
Source
Biochemistry Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Leishmania species are the causative agents of the leishmaniases, a spectrum of neglected tropical diseases.
Amastigote stage parasites exist within macrophages and scavenge host factors for survival, for example, Leishmania species utilise host sphingolipid for synthesis of complex sphingolipid.
In this study L.
mexicana endocytosis was shown to be significantly upregulated in amastigotes, indicating that sphingolipid scavenging may be enhanced.
However, inhibition of host sphingolipid biosynthesis had no significant effect on amastigote proliferation within a macrophage cell line.
In addition, infection itself did not directly influence host biosynthesis.
Notably, in contrast to L.
major, L.
mexicana amastigotes are indicated to possess a complete biosynthetic pathway suggesting that scavenged sphingolipids may be nonessential for proliferation.
This suggested that Old and New World species differ in their interactions with the macrophage host.
This will need to be considered when targeting the Leishmania sphingolipid biosynthetic pathway with novel therapeutics.
American Psychological Association (APA)
Ali, Hayder Z.& Harding, Clare R.& Denny, Paul W.. 2011. Endocytosis and Sphingolipid Scavenging in Leishmania mexicana Amastigotes. Biochemistry Research International،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490904
Modern Language Association (MLA)
Ali, Hayder Z.…[et al.]. Endocytosis and Sphingolipid Scavenging in Leishmania mexicana Amastigotes. Biochemistry Research International No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-490904
American Medical Association (AMA)
Ali, Hayder Z.& Harding, Clare R.& Denny, Paul W.. Endocytosis and Sphingolipid Scavenging in Leishmania mexicana Amastigotes. Biochemistry Research International. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-490904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490904