Joint Inflammation and Early Degeneration Induced by High-Force Reaching Are Attenuated by Ibuprofen in an Animal Model of Work-Related Musculoskeletal Disorder
Joint Authors
Driban, Jeffrey B.
Barr, Ann E.
Sitler, Michael R.
Amin, Mamta
Barbe, Mary F.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
We used our voluntary rat model of reaching and grasping to study the effect of performing a high-repetition and high-force (HRHF) task for 12 weeks on wrist joints.
We also studied the effectiveness of ibuprofen, administered in the last 8 weeks, in attenuating HRHF-induced changes in these joints.
With HRHF task performance, ED1+ and COX2+ cells were present in subchondral radius, carpal bones and synovium; IL-1alpha and TNF-alpha increased in distal radius/ulna/carpal bones; chondrocytes stained with Terminal deoxynucleotidyl Transferase- (TDT-) mediated dUTP-biotin nick end-labeling (TUNEL) increased in wrist articular cartilages; superficial structural changes (e.g., pannus) and reduced proteoglycan staining were observed in wrist articular cartilages.
These changes were not present in normal controls or ibuprofen treated rats, although IL-1alpha was increased in reach limbs of trained controls.
HRHF-induced increases in serum C1,2C (a biomarker of collagen I and II degradation), and the ratio of collagen degradation to synthesis (C1,2C/CPII; the latter a biomarker of collage type II synthesis) were also attenuated by ibuprofen.
Thus, ibuprofen treatment was effective in attenuating HRHF-induced inflammation and early articular cartilage degeneration.
American Psychological Association (APA)
Driban, Jeffrey B.& Barr, Ann E.& Amin, Mamta& Sitler, Michael R.& Barbe, Mary F.. 2011. Joint Inflammation and Early Degeneration Induced by High-Force Reaching Are Attenuated by Ibuprofen in an Animal Model of Work-Related Musculoskeletal Disorder. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-490908
Modern Language Association (MLA)
Driban, Jeffrey B.…[et al.]. Joint Inflammation and Early Degeneration Induced by High-Force Reaching Are Attenuated by Ibuprofen in an Animal Model of Work-Related Musculoskeletal Disorder. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-490908
American Medical Association (AMA)
Driban, Jeffrey B.& Barr, Ann E.& Amin, Mamta& Sitler, Michael R.& Barbe, Mary F.. Joint Inflammation and Early Degeneration Induced by High-Force Reaching Are Attenuated by Ibuprofen in an Animal Model of Work-Related Musculoskeletal Disorder. Journal of Biomedicine and Biotechnology. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-490908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490908