FeNO as a Marker of Airways Inflammation : The Possible Implications in Childhood Asthma Management
Joint Authors
Spagnuolo, Cynzia
Chiarelli, Francesco
Scaparrotta, Alessandra
Consilvio, Nicola Pietro
Rapino, Daniele
Verini, Marcello
Di Pillo, Sabrina
Cingolani, Anna
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The aim of this study was to verify FeNO usefulness, as a marker of bronchial inflammation, in the assessment of therapeutic management of childhood asthma.
We performed a prospective 1-year randomized clinical trial evaluating two groups of 32 children with allergic asthma: “GINA group”, in which therapy was assessed only by GINA guidelines and “FeNO group”, who followed a therapeutic program assessed also on FeNO measurements.
Asthma Severity score (ASs), Asthma Exacerbation Frequency (AEf), and Asthma Therapy score (ATs) were evaluated at the start of the study (T1), 6 months (T2), and 1 year after (T3).
ASs and AEf significantly decreased only in the FeNO group at times T2 and T3 (p[T1-T2] = 0.0001, and p[T1-T3] = 0.01; p[T1-T2] = 0.0001; and p[T1-T3] < 0.0001, resp.).
After six months of follow-up, we found a significant increase of patients under inhaled corticosteroid and/or antileukotrienes in the GINA group compared to the FeNO group (P=.02).
Our data show that FeNO measurements, might be a very useful additional parameter for management of asthma, which is able to avoid unnecessary inhaled corticosteroid and antileukotrienes therapies, however, mantaining a treatment sufficient to obtain a meaningful improvement of asthma.
American Psychological Association (APA)
Verini, Marcello& Consilvio, Nicola Pietro& Di Pillo, Sabrina& Cingolani, Anna& Spagnuolo, Cynzia& Rapino, Daniele…[et al.]. 2010. FeNO as a Marker of Airways Inflammation : The Possible Implications in Childhood Asthma Management. Journal of Allergy،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-490910
Modern Language Association (MLA)
Verini, Marcello…[et al.]. FeNO as a Marker of Airways Inflammation : The Possible Implications in Childhood Asthma Management. Journal of Allergy No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-490910
American Medical Association (AMA)
Verini, Marcello& Consilvio, Nicola Pietro& Di Pillo, Sabrina& Cingolani, Anna& Spagnuolo, Cynzia& Rapino, Daniele…[et al.]. FeNO as a Marker of Airways Inflammation : The Possible Implications in Childhood Asthma Management. Journal of Allergy. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-490910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490910