Enhanced Vascular Endothelial Growth Factor Gene Expression in Ischaemic Skin of Critical Limb Ischaemia Patients
Joint Authors
Bleda, Silvia
Esparza, Leticia
Acin, Francisco
de Haro, Joaquín
Varela, César
Source
International Journal of Vascular Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Objectives.
To perform a quantitative analysis of the vascular endothelial growth factor (VEGF) gene transcription in the skin of ischemic legs and provide information for VEGF in the pathogenesis in critical limb ischemia (CLI).
Methods.
Skin biopsies were obtained from 40 patients with CLI.
Control samples came from 44 patients with chronic venous disease.
VEGF gene expression was analysed using quantitative polymerase chain reaction.
Results.
Patients with CLI had higher skin VEGF expression than control group (RQ: 1.3 ± 0.1 versus 1, P=0.04).
Conclusions.
We found an association between ischemic skin and an elevated VEGF expression in legs from patients with CLI.
These data support that the mechanism for VEGF upregulation in hypoxia conditions is intact and acts appropriately in the ischaemic limbs from patients with CLI.
American Psychological Association (APA)
Bleda, Silvia& de Haro, Joaquín& Acin, Francisco& Varela, César& Esparza, Leticia. 2012. Enhanced Vascular Endothelial Growth Factor Gene Expression in Ischaemic Skin of Critical Limb Ischaemia Patients. International Journal of Vascular Medicine،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-490923
Modern Language Association (MLA)
Bleda, Silvia…[et al.]. Enhanced Vascular Endothelial Growth Factor Gene Expression in Ischaemic Skin of Critical Limb Ischaemia Patients. International Journal of Vascular Medicine No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-490923
American Medical Association (AMA)
Bleda, Silvia& de Haro, Joaquín& Acin, Francisco& Varela, César& Esparza, Leticia. Enhanced Vascular Endothelial Growth Factor Gene Expression in Ischaemic Skin of Critical Limb Ischaemia Patients. International Journal of Vascular Medicine. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-490923
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490923