Complex Variant of Philadelphia Translocation Involving Chromosomes 9, 12, and 22 in a Case with Chronic Myeloid Leukaemia
Joint Authors
Simoni, Giuseppe
Malvestiti, Francesca
Grimi, B.
Maggi, Federico
Oggionni, M.
Agrati, C.
Chinetti, Sara
Cirrincione, S.
Di Meco, A.
Grati, Francesca Romana
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-18
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder included in the broader diagnostic category of myeloproliferative neoplasms, associated with fusion by BCR gene at chromosome 22q11 to ABL1 gene at chromosome 9q34 with the formation of the Philadelphia (Ph) chromosome.
In 2–10% of CML cases, the fusion gene arises in connection with a variant translocation, involving chromosomes 9, 22, and one or more different chromosomes; consequently, the Ph chromosome could be masked within a complex chromosome rearrangement.
In cases with variant Ph translocation a deletion on der(9) may be more frequently observed than in cases with the classical one.
Herein we describe a novel case of CML with complex variant Ph translocation involving chromosomes 9, 12, and 22.
We present the hematologic response and cytogenetic response after Imatinib treatment.
We also speculated the mechanism which had originated the chromosome rearrangement.
American Psychological Association (APA)
Malvestiti, Francesca& Agrati, C.& Chinetti, Sara& Di Meco, A.& Cirrincione, S.& Oggionni, M.…[et al.]. 2014. Complex Variant of Philadelphia Translocation Involving Chromosomes 9, 12, and 22 in a Case with Chronic Myeloid Leukaemia. Case Reports in Genetics،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-490938
Modern Language Association (MLA)
Malvestiti, Francesca…[et al.]. Complex Variant of Philadelphia Translocation Involving Chromosomes 9, 12, and 22 in a Case with Chronic Myeloid Leukaemia. Case Reports in Genetics No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-490938
American Medical Association (AMA)
Malvestiti, Francesca& Agrati, C.& Chinetti, Sara& Di Meco, A.& Cirrincione, S.& Oggionni, M.…[et al.]. Complex Variant of Philadelphia Translocation Involving Chromosomes 9, 12, and 22 in a Case with Chronic Myeloid Leukaemia. Case Reports in Genetics. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-490938
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490938