Treatment of Disseminated Mycobacterial Infection with High-Dose IFN-γ in a Patient with IL-12Rβ1 Deficiency
Joint Authors
Awadallah, Sitalbanat
al-Mazrou, Abdulrahman
Alangari, Abdullah A.
al-Muhsen, Saleh
Boisson-Dupuis, Stéphanie
Casanova, Jean-Laurent
al-Zamil, Fahad
Kambal, Abdelmageed
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-22
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
IFN-γ has been used in the treatment of IL-12Rβ1 deficiency patients with disseminated BCG infection (BCGosis), but the optimal dose to reach efficacy is not clear.
We used IFN-γ in the treatment of a 2.7-year-old patient with IL-12Rβ1 deficiency and refractory BCG-osis.
IFNγ was started at a dose of 50 μg/m2 3 times per week.
The dose was upgraded to 100 mcg/m2 after 3 months, then to 200 mcg/m2 6 months afterwards.
Serum mycobactericidal activity and lymphocytes number and function were evaluated throughout the study.
There was no clinical response to IFN-γ with 50 or 100 μg/m2 doses.
However, there was some response to the 200 μg/m2 dose with no additional adverse effects.
The serum mycobactericidal activity was not significantly different during the whole treatment period.
Lymphocytes proliferation in response to PHA was significantly higher after 3 months of using the highest dose as compared to the lowest dose.
The tuberculin skin test reaction remained persistently negative.
We conclude that in a patient with IL-12Rβ1 deficiency, IFN-γ at a dose of 200 μg/m2, but not at lower dosages, was found to have a noticeable clinical effect with no additional adverse effects.
American Psychological Association (APA)
Alangari, Abdullah A.& al-Zamil, Fahad& al-Mazrou, Abdulrahman& al-Muhsen, Saleh& Boisson-Dupuis, Stéphanie& Awadallah, Sitalbanat…[et al.]. 2010. Treatment of Disseminated Mycobacterial Infection with High-Dose IFN-γ in a Patient with IL-12Rβ1 Deficiency. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-490968
Modern Language Association (MLA)
Alangari, Abdullah A.…[et al.]. Treatment of Disseminated Mycobacterial Infection with High-Dose IFN-γ in a Patient with IL-12Rβ1 Deficiency. Clinical and Developmental Immunology No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-490968
American Medical Association (AMA)
Alangari, Abdullah A.& al-Zamil, Fahad& al-Mazrou, Abdulrahman& al-Muhsen, Saleh& Boisson-Dupuis, Stéphanie& Awadallah, Sitalbanat…[et al.]. Treatment of Disseminated Mycobacterial Infection with High-Dose IFN-γ in a Patient with IL-12Rβ1 Deficiency. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-490968
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490968