Sleep-Wake Cycle and Daytime Sleepiness in the Myotonic Dystrophies
Joint Authors
Placidi, F.
Romigi, Andrea
Liguori, C.
Marciani, Maria Grazia
Massa, Roberto
Albanese, M.
Source
Journal of Neurodegenerative Diseases
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-11-04
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Myotonic dystrophy is the most common type of muscular dystrophy in adults and is characterized by progressive myopathy, myotonia, and multiorgan involvement.
Two genetically distinct entities have been identified, myotonic dystrophy type 1 (DM1 or Steinert’s Disease) and myotonic dystrophy type 2 (DM2).
Myotonic dystrophies are strongly associated with sleep dysfunction.
Sleep disturbances in DM1 are common and include sleep-disordered breathing (SDB), periodic limb movements (PLMS), central hypersomnia, and REM sleep dysregulation (high REM density and narcoleptic-like phenotype).
Interestingly, drowsiness in DM1 seems to be due to a central dysfunction of sleep-wake regulation more than SDB.
To date, little is known regarding the occurrence of sleep disorders in DM2.
SDB (obstructive and central apnoea), REM sleep without atonia, and restless legs syndrome have been described.
Further polysomnographic, controlled studies are strongly needed, particularly in DM2, in order to clarify the role of sleep disorders in the myotonic dystrophies.
American Psychological Association (APA)
Romigi, Andrea& Albanese, M.& Liguori, C.& Placidi, F.& Marciani, Maria Grazia& Massa, Roberto. 2013. Sleep-Wake Cycle and Daytime Sleepiness in the Myotonic Dystrophies. Journal of Neurodegenerative Diseases،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-490974
Modern Language Association (MLA)
Romigi, Andrea…[et al.]. Sleep-Wake Cycle and Daytime Sleepiness in the Myotonic Dystrophies. Journal of Neurodegenerative Diseases No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-490974
American Medical Association (AMA)
Romigi, Andrea& Albanese, M.& Liguori, C.& Placidi, F.& Marciani, Maria Grazia& Massa, Roberto. Sleep-Wake Cycle and Daytime Sleepiness in the Myotonic Dystrophies. Journal of Neurodegenerative Diseases. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-490974
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-490974