Fucoidan Inhibits the Growth of Hepatocellular Carcinoma Independent of Angiogenesis
Joint Authors
Cao, Rui
Wu, Xiong-Zhi
Man, Ya-Nan
Zhang, Shuang-Xia
Zhu, Cong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Some sulphated polysaccharides can bind bFGF but are unable to present bFGF to its high-affinity receptors.
Fucoidan, a sulphated polysaccharide purified from brown algae, which has been used as an anticancer drug in traditional Chinese medicine for hundreds of years, exhibits a variety of anticancer effects, including the induction of the apoptosis and autophagy of cancer cells, the inhibition of the growth of cancer cells, the induction of angiogenesis, and the improvement of antitumour immunity.
Our research shows that fucoidan dose not inhibit the expressions of VEGF, bFGF, IL-8, and heparanase in HCC cells and/or tumour tissues.
Moreover, fucoidan exhibited low affinity for bFGF and could not block the binding of bFGF to heparan sulphated.
Although fucoidan had no effect on angiogenesis and apoptosis in vivo, this drug significantly inhibited the tumour growth and the expression of PCNA.
These results suggest that fucoidan exhibits an anticancer effect in vivo at least partly through inhibition of the proliferation of HCC cells, although it is unable to suppress the angiogenesis induced by HCC.
American Psychological Association (APA)
Zhu, Cong& Cao, Rui& Zhang, Shuang-Xia& Man, Ya-Nan& Wu, Xiong-Zhi. 2013. Fucoidan Inhibits the Growth of Hepatocellular Carcinoma Independent of Angiogenesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-491013
Modern Language Association (MLA)
Zhu, Cong…[et al.]. Fucoidan Inhibits the Growth of Hepatocellular Carcinoma Independent of Angiogenesis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-491013
American Medical Association (AMA)
Zhu, Cong& Cao, Rui& Zhang, Shuang-Xia& Man, Ya-Nan& Wu, Xiong-Zhi. Fucoidan Inhibits the Growth of Hepatocellular Carcinoma Independent of Angiogenesis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-491013
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491013