Increased Left Ventricular Stiffness Impairs Exercise Capacity in Patients with Heart Failure Symptoms Despite Normal Left Ventricular Ejection Fraction
Joint Authors
Kasner, Mario
Schultheiss, Heinz-Peter
Westermann, Dirk
Sinning, David
Schulze, Karsten
Tschöpe, Carsten
Source
Cardiology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-02
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Aims.
Several mechanisms can be involved in the development of exercise intolerance in patients with heart failure despite normal left ventricular ejection fraction (HFNEF) and may include impairment of left ventricular (LV) stiffness.
We therefore investigated the influence of LV stiffness, determined by pressure-volume loop analysis obtained by conductance catheterization, on exercise capacity in HFNEF.
Methods and Results.
27 HFNEF patients who showed LV diastolic dysfunction in pressure-volume (PV) loop analysis performed symptom-limited cardiopulmonary exercise testing (CPET) and were compared with 12 patients who did not show diastolic dysfunction in PV loop analysis.
HFNEF patients revealed a lower peak performance (P=.046), breathing reserve (P=.006), and ventilation equivalent for carbon dioxide production at rest (P=.002).
LV stiffness correlated with peak oxygen uptake (r=-0.636, P<.001), peak oxygen uptake at ventilatory threshold (r=-0.500, P=.009), and ventilation equivalent for carbon dioxide production at ventilatory threshold (r=0.529, P=.005).
Conclusions.
CPET parameters such as peak oxygen uptake, peak oxygen uptake at ventilatory threshold, and ventilation equivalent for carbon dioxide production at ventilatory threshold correlate with LV stiffness.
Increased LV stiffness impairs exercise capacity in HFNEF.
American Psychological Association (APA)
Sinning, David& Kasner, Mario& Westermann, Dirk& Schulze, Karsten& Schultheiss, Heinz-Peter& Tschöpe, Carsten. 2011. Increased Left Ventricular Stiffness Impairs Exercise Capacity in Patients with Heart Failure Symptoms Despite Normal Left Ventricular Ejection Fraction. Cardiology Research and Practice،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-491051
Modern Language Association (MLA)
Sinning, David…[et al.]. Increased Left Ventricular Stiffness Impairs Exercise Capacity in Patients with Heart Failure Symptoms Despite Normal Left Ventricular Ejection Fraction. Cardiology Research and Practice No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-491051
American Medical Association (AMA)
Sinning, David& Kasner, Mario& Westermann, Dirk& Schulze, Karsten& Schultheiss, Heinz-Peter& Tschöpe, Carsten. Increased Left Ventricular Stiffness Impairs Exercise Capacity in Patients with Heart Failure Symptoms Despite Normal Left Ventricular Ejection Fraction. Cardiology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-491051
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491051