From Smoking to Cancers : Novel Targets to Neuronal Nicotinic Acetylcholine Receptors
Joint Authors
Wu, Chih-Hsiung
Lee, Chia-Hwa
Ho, Yuan-Soon
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Cigarette smoking bears a strong etiological association with many neovascularization-related diseases, including cancer, cardiovascular disease, and age-related macular degeneration.
Cigarette smoke is a complex mixture of many compounds, including nicotine, which is the major active and addictive component of tobacco.
Nicotine and its specific metabolized carcinogens directly bind to nicotinic acetylcholine receptors (nAChRs) on cell membranes and trigger the nAChR signal cascade.
The nAChRs were originally thought to be ligand-gated ion channels that modulate physiological processes ranging from neurotransmission to cancer signaling.
For several decades, the nAChRs served as a prototypic molecule for neurotransmitter receptors; however, they are now important therapeutic targets for various diseases, including Alzheimer's and Parkinson's diseases, schizophrenia, and even cancer.
This paper describes recent advances in our understanding of the assembly, activity, and biological functions of nicotinic receptors, as well as developments in the therapeutic application of nicotinic receptor ligands.
American Psychological Association (APA)
Lee, Chia-Hwa& Wu, Chih-Hsiung& Ho, Yuan-Soon. 2011. From Smoking to Cancers : Novel Targets to Neuronal Nicotinic Acetylcholine Receptors. Journal of Oncology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-491092
Modern Language Association (MLA)
Lee, Chia-Hwa…[et al.]. From Smoking to Cancers : Novel Targets to Neuronal Nicotinic Acetylcholine Receptors. Journal of Oncology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-491092
American Medical Association (AMA)
Lee, Chia-Hwa& Wu, Chih-Hsiung& Ho, Yuan-Soon. From Smoking to Cancers : Novel Targets to Neuronal Nicotinic Acetylcholine Receptors. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-491092
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491092