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Studies on Chromatographic Fingerprint and Fingerprinting Profile-Efficacy Relationship of Polygoni Perfoliati Herba
Joint Authors
Tian, Li
Zhou, Xin
Zhao, Yang
Chen, Hua-Guo
Gong, Xiao-Jian
Zhao, Chao
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-19
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Polygoni Perfoliati Herba is widely used in China with antibacterium, anti-inflammatory, expectorant, antitumor, and antivirus activities.
To reveal the mechanisms of the activities of Polygoni Perfoliati Herba, the relationship between the fingerprinting profile and its bioactivities was investigated.
In the present study, high-performance liquid chromatographic (HPLC) fingerprinting method was developed.
The established method was applied to analyze 51 batches of Polygoni Perfoliati Herba samples collected from different locations or in different harvesting times in China.
Chemometrics, including similarity analysis, hierarchical clustering analysis, and principal component analysis, were used to express their similarities.
It was found that similarity values of the samples were in the range of 0.432–0.998.
The results of analgesic tests indicated that Polygoni Perfoliati Herba could significantly inhibit pain induced by hot plate and acetic acid in mice.
The results of anti-inflammatory tests showed that Polygoni Perfoliati Herba had good anti-inflammatory effects (P < 0.01) in two models including dimethyl benzene-induced ear edema and acetic acid-induced peritoneal permeability in mice.
Combining the results from chromatographic fingerprints with those from bioactivities, we found that seven peaks from Polygoni Perfoliati Herba were mainly responsible for analgesic and anti-inflammatory activities.
American Psychological Association (APA)
Tian, Li& Zhao, Yang& Zhou, Xin& Chen, Hua-Guo& Zhao, Chao& Gong, Xiao-Jian. 2013. Studies on Chromatographic Fingerprint and Fingerprinting Profile-Efficacy Relationship of Polygoni Perfoliati Herba. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-491095
Modern Language Association (MLA)
Tian, Li…[et al.]. Studies on Chromatographic Fingerprint and Fingerprinting Profile-Efficacy Relationship of Polygoni Perfoliati Herba. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-491095
American Medical Association (AMA)
Tian, Li& Zhao, Yang& Zhou, Xin& Chen, Hua-Guo& Zhao, Chao& Gong, Xiao-Jian. Studies on Chromatographic Fingerprint and Fingerprinting Profile-Efficacy Relationship of Polygoni Perfoliati Herba. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-491095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491095