Osteosarcomagenesis : Modeling Cancer Initiation in the Mouse
Author
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Osteosarcoma remains a deadly malignancy afflicting adolescents and young adults.
The lack of a precursor and the panoply of genetic aberrations present in identified osteosarcomas makes study of its initiation difficult.
A number of candidate hypotheses have been tested in the mouse, a species with a higher background incidence of osteosarcoma.
Chemical carcinogens, external beam radiation, and bone-seeking heavy metal radioisotopes have all proven to be osteosarcomagenic in wild-type mice.
A number of oncogenes, introduced via integrating viruses or aberrantly activated from heritable genetic loci, participate in and can individually drive osteosarcomagenesis.
Germline and conditional gene ablations in the form of some but not all aneuploidy-inducing genes, conventional tumor suppressors, and factors that function normally in mesenchymal differentiation have also proven osteosarcomagenic, especially in combinations that silence the Rb1 and p53 pathways.
This paper reviews the rich history of mouse models of osteosarcomagenesis, what they have taught us about the human disease, and what future mouse experiments yet promise to teach.
American Psychological Association (APA)
Jones, Kevin B.. 2011. Osteosarcomagenesis : Modeling Cancer Initiation in the Mouse. Sarcoma،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-491160
Modern Language Association (MLA)
Jones, Kevin B.. Osteosarcomagenesis : Modeling Cancer Initiation in the Mouse. Sarcoma No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-491160
American Medical Association (AMA)
Jones, Kevin B.. Osteosarcomagenesis : Modeling Cancer Initiation in the Mouse. Sarcoma. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-491160
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491160