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Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance
Joint Authors
Laranga, Roberta
Lanna, Alessio
Bricogne, Christopher
Dufait, Inès
Escors, David
Liechtenstein, Therese
Padella, Antonella
Breckpot, Karine
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Retroviral and lentiviral vectors have proven to be particularly efficient systems to deliver genes of interest into target cells, either in vivo or in cell cultures.
They have been used for some time for gene therapy and the development of gene vaccines.
Recently retroviral and lentiviral vectors have been used to generate tolerogenic dendritic cells, key professional antigen presenting cells that regulate immune responses.
Thus, three main approaches have been undertaken to induce immunological tolerance; delivery of potent immunosuppressive cytokines and other molecules, modification of intracellular signalling pathways in dendritic cells, and de-targeting transgene expression from dendritic cells using microRNA technology.
In this review we briefly describe retroviral and lentiviral vector biology, and their application to induce immunological tolerance.
American Psychological Association (APA)
Dufait, Inès& Liechtenstein, Therese& Lanna, Alessio& Bricogne, Christopher& Laranga, Roberta& Padella, Antonella…[et al.]. 2012. Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance. Scientifica،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-491161
Modern Language Association (MLA)
Dufait, Inès…[et al.]. Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance. Scientifica No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-491161
American Medical Association (AMA)
Dufait, Inès& Liechtenstein, Therese& Lanna, Alessio& Bricogne, Christopher& Laranga, Roberta& Padella, Antonella…[et al.]. Retroviral and Lentiviral Vectors for the Induction of Immunological Tolerance. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-491161
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491161