The Pak4 Protein Kinase in Breast Cancer
Author
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-27
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Paks4, along with Paks5, and 6 are members of the group B family of p21-activated kinases (Paks).
The Paks play multiple different roles in controlling cell morphology, cell growth, proliferation, and signaling.
Pak4 has essential roles in embryonic development (Qu et al., 2003), but in adults high levels of Pak4 are frequently associated with cancer.
Pak4 has been implicated in several types of cancer (Wells and Jones, 2010; Eswaran et al., 2009; Liu et al., 2008; and Liu et al., 2010) and it is strongly linked to breast cancer (Liu et al., 2008; Liu et al.
2010; Yu et al., 2009; Rafn et al., 2012; and So et al., 2012).
Breast tumors and breast cancer cell lines frequently have high levels of Pak4 (Liu et al., 2008), and overexpression of Pak4 in mammary epithelial cells leads to tumorigenesis in mice (Liu et al., 2010).
This paper summarizes the current work on the role of Pak4 in breast cancer.
American Psychological Association (APA)
Minden, Audrey. 2012. The Pak4 Protein Kinase in Breast Cancer. ISRN Oncology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-491168
Modern Language Association (MLA)
Minden, Audrey. The Pak4 Protein Kinase in Breast Cancer. ISRN Oncology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-491168
American Medical Association (AMA)
Minden, Audrey. The Pak4 Protein Kinase in Breast Cancer. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-491168
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491168