Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies
Joint Authors
Marino, Lorenza
De Agostini, Lisa
Abbate, Carlo
Bagarolo, Renzo
Inglese, Silvia
Cantatore, Alessandra
Mari, Daniela
Trimarchi, Pietro Davide
Pirri, Federico
Viti, Niccolò
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Objective.
We describe a case of dementia with Lewy bodies (DLB) that presented long-lasting preclinical complex polymodal hallucinations.
Background.
Few studies have deeply investigated the characteristics of hallucinations in DLB, especially in the preclinical phase.
Moreover, the clinical phenotype of mild cognitive impairment-(MCI-) DLB is poorly understood.
Methods.
The patient was followed for 4 years and a selective phenomenological and cognitive study was performed at the predementia stage.
Results.
The phenomenological study showed the presence of hypnagogic and hypnopompic hallucinations that allowed us to make a differential diagnosis between DLB and Charles Bonnet syndrome (CBS).
The neuropsychological evaluation showed a multiple domain without amnesia MCI subtype with prefrontal dysexecutive, visuoperceptual, and visuospatial impairments and simultanagnosia, which has not previously been reported in MCI-DLB.
Conclusions.
This study extends the prognostic value of hallucinations for DLB to the preclinical phases.
It supports and refines the MCI-DLB concept and identifies simultanagnosia as a possible early cognitive marker.
Finally, it confirms an association between hallucinations and visuoperceptual impairments at an intermediate stage of the disease course and strongly supports the hypothesis that hallucinations in the earliest stages of DLB may reflect a narcolepsy-like REM-sleep disorder.
American Psychological Association (APA)
Abbate, Carlo& Trimarchi, Pietro Davide& Inglese, Silvia& Viti, Niccolò& Cantatore, Alessandra& De Agostini, Lisa…[et al.]. 2014. Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies. Behavioural Neurology،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-491176
Modern Language Association (MLA)
Abbate, Carlo…[et al.]. Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies. Behavioural Neurology No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-491176
American Medical Association (AMA)
Abbate, Carlo& Trimarchi, Pietro Davide& Inglese, Silvia& Viti, Niccolò& Cantatore, Alessandra& De Agostini, Lisa…[et al.]. Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies. Behavioural Neurology. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-491176
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491176