Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity
Joint Authors
Rosa, Maria do Socorro S.
Amaral, Ana Claudia F.
Rodrigues, Igor A.
Ramos, Aline de S.
Vermelho, Alane Beatriz
Silva, Jefferson Rocha de A.
Gomes, Luciana A.
Ferreira, José Luiz P.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-17
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Promastigote forms of Leishmania amazonensis were treated with different concentrations of two fractions of Curcuma longa cortex rich in turmerones and their respective liposomal formulations in order to evaluate growth inhibition and the minimal inhibitory concentration (MIC).
In addition, cellular alterations of treated promastigotes were investigated under transmission and scanning electron microscopies.
LipoRHIC and LipoRHIWC presented lower MIC, 5.5 and 12.5 μg/mL, when compared to nonencapsulated fractions (125 and 250 μg/mL), respectively, and to ar-turmerone (50 μg/mL).
Parasite growth inhibition was demonstrated to be dose-dependent.
Important morphological changes as rounded body and presence of several roles on plasmatic membrane could be seen on L.
amazonensis promastigotes after treatment with subinhibitory concentration (2.75 μg/mL) of the most active LipoRHIC.
In that sense, the hexane fraction from the turmeric cortex of Curcuma longa incorporated in liposomal formulation (LipoRHIC) could represent good strategy for the development of new antileishmanial agent.
American Psychological Association (APA)
Amaral, Ana Claudia F.& Gomes, Luciana A.& Silva, Jefferson Rocha de A.& Ferreira, José Luiz P.& Ramos, Aline de S.& Rosa, Maria do Socorro S.…[et al.]. 2014. Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity. BioMed Research International،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491228
Modern Language Association (MLA)
Amaral, Ana Claudia F.…[et al.]. Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity. BioMed Research International No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-491228
American Medical Association (AMA)
Amaral, Ana Claudia F.& Gomes, Luciana A.& Silva, Jefferson Rocha de A.& Ferreira, José Luiz P.& Ramos, Aline de S.& Rosa, Maria do Socorro S.…[et al.]. Liposomal Formulation of Turmerone-Rich Hexane Fractions from Curcuma longa Enhances Their Antileishmanial Activity. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-491228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491228