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Regulation of Pancreatic microRNA-7 Expression
Joint Authors
Kredo-Russo, Sharon
Hornstein, Eran
Walker, Michael D.
Ness, Avital
Mandelbaum, Amitai D.
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-17
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Genome-encoded microRNAs (miRNAs) provide a posttranscriptional regulatory layer, which is important for pancreas development.
Differentiation of endocrine cells is controlled by a network of pancreatic transcription factors including Ngn3 and NeuroD/Beta2.
However, how specific miRNAs are intertwined into this transcriptional network is not well understood.
Here, we characterize the regulation of microRNA-7 (miR-7) by endocrine-specific transcription factors.
Our data reveal that three independent miR-7 genes are coexpressed in the pancreas.
We have identified conserved blocks upstream of pre-miR-7a-2 and pre-miR-7b and demonstrated by functional assays that they possess promoter activity, which is increased by the expression of NeuroD/Beta2.
These data suggest that the endocrine specificity of miR-7 expression is governed by transcriptional mechanisms and involves members of the pancreatic endocrine network of transcription factors.
American Psychological Association (APA)
Kredo-Russo, Sharon& Ness, Avital& Mandelbaum, Amitai D.& Walker, Michael D.& Hornstein, Eran. 2012. Regulation of Pancreatic microRNA-7 Expression. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-491253
Modern Language Association (MLA)
Kredo-Russo, Sharon…[et al.]. Regulation of Pancreatic microRNA-7 Expression. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-491253
American Medical Association (AMA)
Kredo-Russo, Sharon& Ness, Avital& Mandelbaum, Amitai D.& Walker, Michael D.& Hornstein, Eran. Regulation of Pancreatic microRNA-7 Expression. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-491253
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491253