Antimony Resistance in Leishmania, Focusing on Experimental Research
Joint Authors
Jeddi, Fakhri
Mary, Charles
Piarroux, Renaud
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Leishmaniases are parasitic diseases that spread in many countries with a prevalence of 12 million cases.
There are few available treatments and antimonials are still of major importance in the therapeutic strategies used in most endemic regions.
However, resistance toward these compounds has recently emerged in areas where the replacement of these drugs is mainly limited by the cost of alternative molecules.
In this paper, we reviewed the studies carried out on antimonial resistance in Leishmania.
Several common limitations of these works are presented before prevalent approaches to evidence antimonial resistance are related.
Afterwards, phenotypic determination of resistance is described, then confronted to clinical outcome.
Finally, we detail molecular mechanisms and targets involved in resistance and already identified in vitro within selected mutant strains or in clinical isolates.
American Psychological Association (APA)
Jeddi, Fakhri& Piarroux, Renaud& Mary, Charles. 2011. Antimony Resistance in Leishmania, Focusing on Experimental Research. Journal of Tropical Medicine،Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-491264
Modern Language Association (MLA)
Jeddi, Fakhri…[et al.]. Antimony Resistance in Leishmania, Focusing on Experimental Research. Journal of Tropical Medicine No. 2011 (2011), pp.1-15.
https://search.emarefa.net/detail/BIM-491264
American Medical Association (AMA)
Jeddi, Fakhri& Piarroux, Renaud& Mary, Charles. Antimony Resistance in Leishmania, Focusing on Experimental Research. Journal of Tropical Medicine. 2011. Vol. 2011, no. 2011, pp.1-15.
https://search.emarefa.net/detail/BIM-491264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491264