Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease
Joint Authors
Hartmann, Tobias
Grösgen, Sven
Grimm, Marcus O. W.
Haupenthal, Viola J.
Müller, Ulrike
Hundsdörfer, Benjamin
Grimm, Heike S.
Rothhaar, Tatjana L.
Burg, Verena K.
Friess, Petra
Fassbender, Klaus
Riemenschneider, Matthias
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Lipids play an important role as risk or protective factors in Alzheimer's disease (AD), a disease biochemically characterized by the accumulation of amyloid beta peptides (Aβ), released by proteolytic processing of the amyloid precursor protein (APP).
Changes in sphingolipid metabolism have been associated to the development of AD.
The key enzyme in sphingolipid de novo synthesis is serine-palmitoyl-CoA transferase (SPT).
In the present study we identified a new physiological function of APP in sphingolipid synthesis.
The APP intracellular domain (AICD) was found to decrease the expression of the SPT subunit SPTLC2, the catalytic subunit of the SPT heterodimer, resulting in that decreased SPT activity.
AICD function was dependent on Fe65 and SPTLC2 levels are increased in APP knock-in mice missing a functional AICD domain.
SPTLC2 levels are also increased in familial and sporadic AD postmortem brains, suggesting that SPT is involved in AD pathology.
American Psychological Association (APA)
Grimm, Marcus O. W.& Grösgen, Sven& Rothhaar, Tatjana L.& Burg, Verena K.& Hundsdörfer, Benjamin& Haupenthal, Viola J.…[et al.]. 2011. Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-491269
Modern Language Association (MLA)
Grimm, Marcus O. W.…[et al.]. Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-491269
American Medical Association (AMA)
Grimm, Marcus O. W.& Grösgen, Sven& Rothhaar, Tatjana L.& Burg, Verena K.& Hundsdörfer, Benjamin& Haupenthal, Viola J.…[et al.]. Intracellular APP Domain Regulates Serine-Palmitoyl-CoA Transferase Expression and Is Affected in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-491269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491269