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Bevacizumab-Induced Reversible Thrombocytopenia in a Patient with Adenocarcinoma of Colon : Rare Adverse Effect of Bevacizumab
Joint Authors
Bhargava, Manorama
Kumar, Jeevan
Aggarwal, Shyam
Source
Case Reports in Oncological Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-10
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
We report a case of bevacizumab- (BEV-) induced thrombocytopenia in a 59-year-old man with adenocarcinoma of colon.
After colectomy, the patient was treated with twelve cycles of FOLFOX-4 (folinic acid, 5-fluorouracil, and oxaliplatin) regimen.
On relapse, he was treated with FOLFIRI (folinic acid, 5-fluorouracil, and irinotecan) regimen along with BEV 10 mg/kg for 6 cycles.
After that, BEV was continued for maintenance as a single agent at an interval of three weeks.
After the13th cycle of BEV, the patient developed melena with epistaxis and thrombocytopenia, from which he recovered on withdrawal of BEV.
On rechallenge with half the initial dose, there was once again a reversible drop in platelet count.
The proposed mechanism of thrombocytopenia may be immune-mediated peripheral destruction of platelets.
American Psychological Association (APA)
Kumar, Jeevan& Bhargava, Manorama& Aggarwal, Shyam. 2012. Bevacizumab-Induced Reversible Thrombocytopenia in a Patient with Adenocarcinoma of Colon : Rare Adverse Effect of Bevacizumab. Case Reports in Oncological Medicine،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-491271
Modern Language Association (MLA)
Kumar, Jeevan…[et al.]. Bevacizumab-Induced Reversible Thrombocytopenia in a Patient with Adenocarcinoma of Colon : Rare Adverse Effect of Bevacizumab. Case Reports in Oncological Medicine No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-491271
American Medical Association (AMA)
Kumar, Jeevan& Bhargava, Manorama& Aggarwal, Shyam. Bevacizumab-Induced Reversible Thrombocytopenia in a Patient with Adenocarcinoma of Colon : Rare Adverse Effect of Bevacizumab. Case Reports in Oncological Medicine. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-491271
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491271