The Leishmania HSP20 Is Antigenic during Natural Infections, but, as DNA Vaccine, It does not Protect BALBc Mice against Experimental L. amazonensis Infection
Joint Authors
Requena, Jose M.
Folgueira, Cristina
Carrión, Javier
Montalvo-Álvarez, Ana M.
Cañavate, Carmen
Monzote-Fidalgo, Lianet
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-04-03
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Protozoa of the genus Leishmania are causative agents of leishmaniasis, an important health problem in both human and veterinary medicine.
Here, we describe a new heat shock protein (HSP) in Leishmania, belonging to the small HSP (sHSP) family in kinetoplastids.
The protein is highly conserved in different Leishmania species, showing instead significant divergence with sHSP's from other organisms.
The humoral response elicited against this protein during Leishmania infection has been investigated in natural infected humans and dogs, and in experimentally infected hamsters.
Leishmania HSP20 is a prominent antigen for canine hosts; on the contrary, the protein seems to be a poor antigen for human immune system.
Time-course analysis of appearance of anti-HSP20 antibodies in golden hamsters indicated that these antibodies are produced at late stages of the infection, when clinical symptoms of disease are patent.
Finally, the protective efficacy of HSP20 was assessed in mice using a DNA vaccine approach prior to challenge with Leishmania amazonensis.
American Psychological Association (APA)
Montalvo-Álvarez, Ana M.& Folgueira, Cristina& Carrión, Javier& Monzote-Fidalgo, Lianet& Cañavate, Carmen& Requena, Jose M.. 2008. The Leishmania HSP20 Is Antigenic during Natural Infections, but, as DNA Vaccine, It does not Protect BALBc Mice against Experimental L. amazonensis Infection. Journal of Biomedicine and Biotechnology،Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-491272
Modern Language Association (MLA)
Montalvo-Álvarez, Ana M.…[et al.]. The Leishmania HSP20 Is Antigenic during Natural Infections, but, as DNA Vaccine, It does not Protect BALBc Mice against Experimental L. amazonensis Infection. Journal of Biomedicine and Biotechnology No. 2008 (2008), pp.1-9.
https://search.emarefa.net/detail/BIM-491272
American Medical Association (AMA)
Montalvo-Álvarez, Ana M.& Folgueira, Cristina& Carrión, Javier& Monzote-Fidalgo, Lianet& Cañavate, Carmen& Requena, Jose M.. The Leishmania HSP20 Is Antigenic during Natural Infections, but, as DNA Vaccine, It does not Protect BALBc Mice against Experimental L. amazonensis Infection. Journal of Biomedicine and Biotechnology. 2008. Vol. 2008, no. 2008, pp.1-9.
https://search.emarefa.net/detail/BIM-491272
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491272