Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model
Joint Authors
Chen, Huaiqing
Yu, Fengxu
Dian, Ke
Meng, Wei
Zhang, Eryong
Zhang, Jianmin
Shi, Yingkang
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-09-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The purpose of this study was to determine the concentration polarization of high-density lipoprotein (HDL) at the surface of the carotid artery under conditions of steady flow and to establish its relationship with shear stress using an in vitro vascular simulation model of carotid bifurcation.
Shear stress, HDL concentration at the surface, and the ratio of HDL concentration at the surface to concentration in bulk flow were measured at different locations within the model under high-speed (1.451 m/s) and low-speed (0.559 m/s) flow.
HDL showed concentration polarization at the surface of the carotid artery model, particularly in the internal carotid artery sinus.
With decreasing flow velocity, the shear stress at the surface also decreased, and HDL concentration polarization increased.
The concentration polarization of HDL was negatively and strongly correlated with shear stress at both low- (r=−0.872, P<.001) and high-speed flow (r=−0.592, P=.0018).
American Psychological Association (APA)
Meng, Wei& Yu, Fengxu& Chen, Huaiqing& Zhang, Jianmin& Dian, Ke& Shi, Yingkang…[et al.]. 2009. Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-491306
Modern Language Association (MLA)
Dian, Ke…[et al.]. Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-491306
American Medical Association (AMA)
Meng, Wei& Yu, Fengxu& Chen, Huaiqing& Zhang, Jianmin& Dian, Ke& Shi, Yingkang…[et al.]. Concentration Polarization of High-Density Lipoprotein and Its Relation with Shear Stress in an In Vitro Model. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-491306
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491306