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Plasmodium Riboprotein PfP0 Induces a Deviant Humoral Immune Response in Balbc Mice
Joint Authors
Rajagopal, Sudarsan
Garg, Swati
Patel, Kalpesh
Pathak, Sulabha
Sharma, Shobhona
Ravindran, Balachandran
Pied, Sylviane
Das, Bidyut
Rajeshwari, K.
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Passive immunization with antibodies to recombinant Plasmodium falciparum P0 riboprotein (rPfP0, 61–316 amino acids) provides protection against malaria.
Carboxy-terminal 16 amino acids of the protein (PfP0C0) are conserved and show 69% identity to human and mouse P0.
Antibodies to this domain are found in 10–15% of systemic lupus erythematosus patients.
We probed the nature of humoral response to PfP0C0 by repeatedly immunizing mice with rPfP0.
We failed to raise stable anti-PfP0C0 hybridomas from any of the 21 mice.
The average serum anti-PfP0C0 titer remained low (5.1±1.3×104).
Pathological changes were observed in the mice after seven boosts.
Adsorption with dinitrophenyl hapten revealed that the anti-PfP0C0 response was largely polyreactive.
This polyreactivity was distributed across all isotypes.
Similar polyreactive responses to PfP0 and PfP0C0 were observed in sera from malaria patients.
Our data suggests that PfP0 induces a deviant humoral response, and this may contribute to immune evasion mechanisms of the parasite.
American Psychological Association (APA)
Pathak, Sulabha& Rajeshwari, K.& Garg, Swati& Rajagopal, Sudarsan& Patel, Kalpesh& Das, Bidyut…[et al.]. 2012. Plasmodium Riboprotein PfP0 Induces a Deviant Humoral Immune Response in Balbc Mice. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-491307
Modern Language Association (MLA)
Pathak, Sulabha…[et al.]. Plasmodium Riboprotein PfP0 Induces a Deviant Humoral Immune Response in Balbc Mice. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-491307
American Medical Association (AMA)
Pathak, Sulabha& Rajeshwari, K.& Garg, Swati& Rajagopal, Sudarsan& Patel, Kalpesh& Das, Bidyut…[et al.]. Plasmodium Riboprotein PfP0 Induces a Deviant Humoral Immune Response in Balbc Mice. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-491307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491307