Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia
Joint Authors
Wattanathorn, Jintanaporn
Sutalangka, Chatchada
Muchimapura, Supaporn
Thukham-mee, Wipawee
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
To date, the preventive strategy against dementia is still essential due to the rapid growth of its prevalence and the limited therapeutic efficacy.
Based on the crucial role of oxidative stress in age-related dementia and the antioxidant and nootropic activities of Moringa oleifera, the enhancement of spatial memory and neuroprotection of M.
oleifera leaves extract in animal model of age-related dementia was determined.
The possible underlying mechanism was also investigated.
Male Wistar rats, weighing 180–220 g, were orally given M.
oleifera leaves extract at doses of 100, 200, and 400 mg/kg at a period of 7 days before and 7 days after the intracerebroventricular administration of AF64A bilaterally.
Then, they were assessed memory, neuron density, MDA level, and the activities of SOD, CAT, GSH-Px, and AChE in hippocampus.
The results showed that the extract improved spatial memory and neurodegeneration in CA1, CA2, CA3, and dentate gyrus of hippocampus together with the decreased MDA level and AChE activity but increased SOD and CAT activities.
Therefore, our data suggest that M.
oleifera leaves extract is the potential cognitive enhancer and neuroprotectant.
The possible mechanism might occur partly via the decreased oxidative stress and the enhanced cholinergic function.
However, further explorations concerning active ingredient(s) are still required.
American Psychological Association (APA)
Sutalangka, Chatchada& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Thukham-mee, Wipawee. 2013. Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491317
Modern Language Association (MLA)
Sutalangka, Chatchada…[et al.]. Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-491317
American Medical Association (AMA)
Sutalangka, Chatchada& Wattanathorn, Jintanaporn& Muchimapura, Supaporn& Thukham-mee, Wipawee. Moringa oleifera Mitigates Memory Impairment and Neurodegeneration in Animal Model of Age-Related Dementia. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-491317
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491317