Biological Basis for Increased Sensitivity to Radiation Therapy in HPV-Positive Head and Neck Cancers
Joint Authors
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-03
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Although development of head and neck squamous cell carcinomas (HNSCCs) is commonly linked to the consumption of tobacco and alcohol, a link between human papillomavirus (HPV) infection and a subgroup of head and neck cancers has been established.
These HPV-positive tumors represent a distinct biological entity with overexpression of viral oncoproteins E6 and E7.
It has been shown in several clinical studies that HPV-positive HNSCCs have a more favorable outcome and greater response to radiotherapy.
The reason for improved prognosis of HPV-related HNSCC remains speculative, but it could be owned to multiple factors.
One hypothesis is that HPV-positive cells are intrinsically more sensitive to standard therapies and thus respond better to treatment.
Another possibility is that HPV-positive tumors uniquely express viral proteins that induce an immune response during therapy that helps clear tumors and prevents recurrence.
Here, we will review current evidence for the biological basis of increased radiosensitivity in HPV-positive HNSCC.
American Psychological Association (APA)
Bol, V.& Grégoire, V.. 2014. Biological Basis for Increased Sensitivity to Radiation Therapy in HPV-Positive Head and Neck Cancers. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491322
Modern Language Association (MLA)
Bol, V.& Grégoire, V.. Biological Basis for Increased Sensitivity to Radiation Therapy in HPV-Positive Head and Neck Cancers. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-491322
American Medical Association (AMA)
Bol, V.& Grégoire, V.. Biological Basis for Increased Sensitivity to Radiation Therapy in HPV-Positive Head and Neck Cancers. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-491322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491322