Induction of Apoptosis in Human Multiple Myeloma Cell Lines by Ebselen via Enhancing the Endogenous Reactive Oxygen Species Production
Joint Authors
Zhang, Liang
Zhou, Liwei
Du, Jia
Cheng, Yi
Wang, Dong
Peng, Yang
Xie, Jiayin
Li, Mengxia
Qian, Chengyuan
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-27
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Ebselen a selenoorganic compound showing glutathione peroxidase like activity is an anti-inflammatory and antioxidative agent.
Its cytoprotective activity has been investigated in recent years.
However, experimental evidence also shows that ebselen causes cell death in several cancer cell types whose mechanism has not yet been elucidated.
In this study, we examined the effect of ebselen on multiple myeloma (MM) cell lines in vitro.
The results showed that ebselen significantly enhanced the production of reactive oxygen species (ROS) accompanied by cell viability decrease and apoptosis rate increase.
Further studies revealed that ebselen can induce Bax redistribution from the cytosol to mitochondria leading to mitochondrial membrane potential ΔΨm changes and cytochrome C release from the mitochondria to cytosol.
Furtherly, we found that exogenous addition of N-acetyl cysteine (NAC) completely diminished the cell damage induced by ebselen.
This result suggests that relatively high concentration of ebselen can induce MM cells apoptosis in culture by enhancing the production of endogenous ROS and triggering mitochondria mediated apoptotic pathway.
American Psychological Association (APA)
Zhang, Liang& Zhou, Liwei& Du, Jia& Li, Mengxia& Qian, Chengyuan& Cheng, Yi…[et al.]. 2014. Induction of Apoptosis in Human Multiple Myeloma Cell Lines by Ebselen via Enhancing the Endogenous Reactive Oxygen Species Production. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-491329
Modern Language Association (MLA)
Zhang, Liang…[et al.]. Induction of Apoptosis in Human Multiple Myeloma Cell Lines by Ebselen via Enhancing the Endogenous Reactive Oxygen Species Production. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-491329
American Medical Association (AMA)
Zhang, Liang& Zhou, Liwei& Du, Jia& Li, Mengxia& Qian, Chengyuan& Cheng, Yi…[et al.]. Induction of Apoptosis in Human Multiple Myeloma Cell Lines by Ebselen via Enhancing the Endogenous Reactive Oxygen Species Production. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-491329
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491329