![](/images/graphics-bg.png)
Aggressive versus Low Dose Inhibition of the Renin-Angiotensin System for the Treatment of Microalbuminuria in Type 2 Diabetic Patients : A Pilot Study
Joint Authors
Tareen, N.
Aguilar, V.
Duran, P.
Davidson, M. B.
Lee, M. L.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-18
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
This study compares low dose versus aggressive inhibition of the renin angiotensin system (RAS) to treat microalbuminuria (MA).
Methods.
Patients with MA after a run-in period to control BP to <130/80 mm Hg with 10 mg benazepril plus other drugs and HbA1c levels to <8.0% were randomized to either continue 10 mg benazepril (N=12) or to take maximal doses of benazepril plus losartan in monthly stepwise increases to achieve normoalbuminuria (N=11).
Because MA is associated with CVD and inflammation, carotid intima medial thickness (CIMT) and endothelial function by peripheral arterial tonometry (PAT) as surrogate indices of atherosclerosis and highly sensitive C-reactive protein (hs-CRP) to assess inflammation were measured every six months.
Results.
BP, HbA1c levels, albumin : creatinine ratios, CIMT, PAT, and hs-CRP did not differ over a mean of 12 months between the two groups.
Conclusions.
Aggressive inhibition of the RAS is unnecessary to treat MA.
American Psychological Association (APA)
Davidson, M. B.& Tareen, N.& Duran, P.& Aguilar, V.& Lee, M. L.. 2011. Aggressive versus Low Dose Inhibition of the Renin-Angiotensin System for the Treatment of Microalbuminuria in Type 2 Diabetic Patients : A Pilot Study. ISRN Endocrinology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-491330
Modern Language Association (MLA)
Davidson, M. B.…[et al.]. Aggressive versus Low Dose Inhibition of the Renin-Angiotensin System for the Treatment of Microalbuminuria in Type 2 Diabetic Patients : A Pilot Study. ISRN Endocrinology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-491330
American Medical Association (AMA)
Davidson, M. B.& Tareen, N.& Duran, P.& Aguilar, V.& Lee, M. L.. Aggressive versus Low Dose Inhibition of the Renin-Angiotensin System for the Treatment of Microalbuminuria in Type 2 Diabetic Patients : A Pilot Study. ISRN Endocrinology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-491330
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491330