Triple-Negative Breast Cancer : Adjuvant Therapeutic Options
Joint Authors
Gucalp, Ayca
Traina, Tiffany A.
Source
Chemotherapy Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Triple-negative breast cancer (TNBC), a subtype distinguished by negative immunohistochemical assays for expression of the estrogen and progesterone receptors (ER/PR) and human epidermal growth factor receptor-2(HER2) represents 15% of all breast cancers.
Patients with TNBC generally experience a more aggressive clinical course with increased risk of disease progression and poorer overall survival.
Furthermore, this subtype accounts for a disproportionate number of disease-related mortality in part due to its aggressive natural history and our lack of effective targeted agents beyond conventional cytotoxic chemotherapy.
In this paper, we will review the epidemiology, risk factors, prognosis, and the molecular and clinicopathologic features that distinguish TNBC from other subtypes of breast cancer.
In addition, we will examine the available data for the use of cytotoxic chemotherapy in the treatment of TNBC in both the neoadjuvant and adjuvant setting and explore the ongoing development of newer targeted agents.
American Psychological Association (APA)
Gucalp, Ayca& Traina, Tiffany A.. 2011. Triple-Negative Breast Cancer : Adjuvant Therapeutic Options. Chemotherapy Research and Practice،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-491339
Modern Language Association (MLA)
Gucalp, Ayca& Traina, Tiffany A.. Triple-Negative Breast Cancer : Adjuvant Therapeutic Options. Chemotherapy Research and Practice No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-491339
American Medical Association (AMA)
Gucalp, Ayca& Traina, Tiffany A.. Triple-Negative Breast Cancer : Adjuvant Therapeutic Options. Chemotherapy Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-491339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491339