Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress
Joint Authors
Ayala, Victoria
Boada, Jordi
Naudi, Alba
Prat, Joan
Pamplona, Reinald
Cassanye, Anna
Serrano, Jose
Jove, Mariona
Gonzalo, Hugo
Portero-Otin, Manuel
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-02
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Oxidative stress has been implicated in diabetes long-term complications.
In this paper, we summarize the growing evidence suggesting that hyperglycemia-induced overproduction of superoxide by mitochondrial electron transport chain triggers a maladaptive response by affecting several metabolic and signaling pathways involved in the pathophysiology of cellular dysfunction and diabetic complications.
In particular, it is our goal to describe physiological mechanisms underlying the mitochondrial free radical production and regulation to explain the oxidative stress derived from a high intracellular glucose concentration and the resulting maladaptive response that leads to a cellular dysfunction and pathological state.
Finally, we outline potential therapies for diabetes focused to the prevention of mitochondrial oxidative damage.
American Psychological Association (APA)
Naudi, Alba& Jove, Mariona& Ayala, Victoria& Cassanye, Anna& Serrano, Jose& Gonzalo, Hugo…[et al.]. 2012. Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-491340
Modern Language Association (MLA)
Naudi, Alba…[et al.]. Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress. Experimental Diabetes Research No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-491340
American Medical Association (AMA)
Naudi, Alba& Jove, Mariona& Ayala, Victoria& Cassanye, Anna& Serrano, Jose& Gonzalo, Hugo…[et al.]. Cellular Dysfunction in Diabetes as Maladaptive Response to Mitochondrial Oxidative Stress. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-491340
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491340