Plasmodium falciparum Malaria Complicated by Symmetrical Peripheral Gangrene, Bowel Ischemia, Repeated Candidemia, and Bacteraemia
Joint Authors
Masse, Emeline
Hantson, Philippe
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 63-year-old Caucasian woman developed severe Plasmodium falciparum malaria when travelling back from Cameroun.
No antimalarial chemoprophylaxis had been observed.
The patient was immediately admitted to the intensive care unit after evidence of multiple organ failure (coma, shock, acute respiratory distress syndrome, acute renal failure, etc.).
However, initial parasitemia was less than 1%.
The patient was managed by intravenous quinine and norepinephrine infusion due to refractory shock.
The patient developed as an early complication ischemic lesions of both arms and feet.
In addition to laboratory changes consistent with disseminated intravascular coagulation, there was also evidence for a low activity of the von Willebrand factor (VWF) cleaving protease ADAMTS13.
Later complications included repeated candidemia and bacteraemia despite appropriate therapy; the origin appeared to be diffuse ischemic injury of the gastrointestinal tract.
The patient ultimately recovered, but quadriamputation was necessary to treat symmetrical peripheral gangrene (SPG).
In severe Plasmodium falciparum malaria, ischemic changes may be due to microvascular obstruction, but, in patients with low parasitemia, other endothelial factors may also be involved as observed in other groups of thrombotic microangiopathies.
American Psychological Association (APA)
Masse, Emeline& Hantson, Philippe. 2014. Plasmodium falciparum Malaria Complicated by Symmetrical Peripheral Gangrene, Bowel Ischemia, Repeated Candidemia, and Bacteraemia. Case Reports in Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-491379
Modern Language Association (MLA)
Masse, Emeline& Hantson, Philippe. Plasmodium falciparum Malaria Complicated by Symmetrical Peripheral Gangrene, Bowel Ischemia, Repeated Candidemia, and Bacteraemia. Case Reports in Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-491379
American Medical Association (AMA)
Masse, Emeline& Hantson, Philippe. Plasmodium falciparum Malaria Complicated by Symmetrical Peripheral Gangrene, Bowel Ischemia, Repeated Candidemia, and Bacteraemia. Case Reports in Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-491379
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491379