Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity : The Pilot Study
Joint Authors
Gawlewicz-Mroczka, A.
Sanak, Marek
Ćmiel, A.
Mastalerz, L.
Kumik, J.
Celejewska-Wójcik, N.
Szczeklik, A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Special regulatory role of eicosanoids has been postulated in aspirin-induced asthma.
Objective.
To investigate effects of aspirin on exhaled breath condensate (EBC) levels of eicosanoids in patients with asthma.
Methods.
We determined EBC eicosanoid concentrations using gas chromatography/mass spectrometry (GC-MS) and high-performance liquid chromatography/mass spectrometry (HPLC-MS2) or both.
Determinations were performed at baseline and following bronchial aspirin challenge, in two well-defined phenotypes of asthma: aspirin-sensitive and aspirin-tolerant patients.
Results.
Aspirin precipitated bronchial reactions in all aspirin-sensitive, but in none of aspirin-tolerant patients (ATAs).
At baseline, eicosanoids profile did not differ between both asthma groups except for lipoxygenation products: 5- and 15-hydroxyeicosatetraenoic acid (5-, 15-HETE) which were higher in aspirin-induced asthma (AIA) than inaspirin-tolerant subjects.
Following aspirin challenge the total levels of cysteinyl-leukotrienes (cys-LTs) remained unchanged in both groups.
The dose of aspirin had an effect on magnitude of the response of the exhaled cys-LTs and prostanoids levels only in AIA subjects.
Conclusion.
The high baseline eicosanoid profiling of lipoxygenation products 5- and 15-HETE in EBC makes it possible to detect alterations in aspirin-sensitive asthma.
Cysteinyl-leukotrienes, and eoxins levels in EBC after bronchial aspirin administration in stable asthma patients cannot be used as a reliable diagnostic index for aspirin hypersensitivity.
American Psychological Association (APA)
Mastalerz, L.& Sanak, Marek& Kumik, J.& Gawlewicz-Mroczka, A.& Celejewska-Wójcik, N.& Ćmiel, A.…[et al.]. 2012. Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity : The Pilot Study. Journal of Allergy،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-491387
Modern Language Association (MLA)
Mastalerz, L.…[et al.]. Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity : The Pilot Study. Journal of Allergy No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-491387
American Medical Association (AMA)
Mastalerz, L.& Sanak, Marek& Kumik, J.& Gawlewicz-Mroczka, A.& Celejewska-Wójcik, N.& Ćmiel, A.…[et al.]. Exhaled Eicosanoids following Bronchial Aspirin Challenge in Asthma Patients with and without Aspirin Hypersensitivity : The Pilot Study. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-491387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-491387